Cyclenium Pharma is a privately held biotechnology company employing its proprietary next generation CMRT™ small-molecule macrocycle technology for drug discovery against difficult disease targets, on its own and in partnership with leading academic and non-profit organizations, as well as innovative pharmaceutical and biotechnology companies worldwide.
Cyclenium was founded by management and research staff from Tranzyme Pharma, one of the pioneers in the generation and use of small molecule macrocycles for drug discovery. Tranzyme was the first company to prepare and use large screening libraries (50,000+) of synthetic macrocyclic compounds to identify and optimize multiple lead candidates that progressed to late stage clinical trials (Phase 2b, Phase 3). Subsequent to Tranzyme’s merger with Ocera Therapeutics (now part of Mallinckrodt Plc (NYSE: MNK)) and closure of its Canadian R & D site, the founders created, based on their vast experience, profound knowledge base in macrocyclic chemistry, and exceptional track record of successful lead and clinical candidate generation, a proprietary next generation technology that addresses the deficiencies of earlier efforts in this rapidly growing field.
Ph.D., DABT, President, Chief Executive Officer &
Chief Scientific Officer
Ph.D., Chief Operating Officer & Corporate Secretary
Dr. Thomas was Senior Vice President, Research & Preclinical Development at Tranzyme Pharma for over seven years prior to co-founding Cyclenium Pharma. He is a highly accomplished biochemist and toxicologist with an extensive and productive career in drug discovery and development. He began his career with CIBA-GEIGY in Basel, Switzerland in 1990 and became the Head of Toxicology and Preclinical Safety at CIBA-GEIGY Pharmaceuticals UK in 1994.
Following the merger with Sandoz in 1997, Dr. Thomas spent the next eight years with Novartis Pharma, where he held several top-level management positions in Europe and the U.S., culminating in his appointment as Executive Director, Global Project Manager and Leader of the PRIDE (Proof of Research In Development) Team Oncology in East Hanover, NJ, with responsibility for the early development portfolio from end-stage research to clinical proof of concept.
While at Novartis, he directed the preclinical development of more than 25 drug candidates, including such important marketed drugs as Diovan® for hypertension and Gleevec® for chronic myeloid leukemia.
He joined Tranzyme from LymphoSign Inc., where he served as Vice President, Research and Development.
Dr. Thomas received his Ph.D. in biochemistry and organic chemistry from the University of Hannover, Germany. He is an author of over 130 scientific articles, book chapters and abstracts as well as a co-inventor on numerous patents.
Prior to co-founding Cyclenium Pharma, Dr. Peterson was Vice President, IP & Operations at Tranzyme Pharma, where he led the chemistry R & D efforts during the technology development stage of the company and the initiation of its GPCR-based drug discovery programs. He later focused on building and maintaining an extensive portfolio of over 120 patents and applications protecting Tranzyme’s pioneering technology and pharmaceutical product candidates.
Previously with Monsanto and Advanced ChemTech, he has worked in a variety of research areas including structure-based design, solid phase organic chemistry, combinatorial libraries, synthetic automation, heterocycles, unnatural amino acids, peptides and peptidomimetics.
Dr. Peterson received his Ph.D. in Organic Chemistry from Washington State University and conducted post-doctoral research at the University of Minnesota, Department of Medicinal Chemistry. He is author or co-author of over 85 publications and abstracted presentations plus three book chapters, as well as co-inventor on 30 patents. In addition, he is co-editor of a seminal book in the area of small molecule macrocycle drug discovery:
Practical Medicinal Chemistry with Macrocycles: Design, Synthesis and Case Studies.